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Effect of Probiotics on Gut-Liver Axis of Alcoholic Liver Disease (EPALD)
Background/Aims: The investigators explored the therapeutic effects of probiotics in patients with AH. Methods: Between September 2010 and April 2012, the investigators conducted a 7-day, double-controlled, randomized, prospective clinical trial comparing the efficacy of probiotics in improving liver enzymes, LPS, pro-inflammatory cytokines. AH was defined as an aspartate aminotransferase (AST)/alanine aminotransferase (ALT) \> 2 and elevated AST (ALT) level with an alcohol consumption history within 48 hours. Patients were randomized to receive 7 days of probiotics (1500 mg/day) or placebo. The levels of liver enzymes, modified Discriminant Function (mDF), LPS, and pro-inflammatory cytokines were checked at baseline and again after therapy.
Details
| Lead sponsor | Chuncheon Sacred Heart Hospital |
|---|---|
| Phase | Phase 4 |
| Status | COMPLETED |
| Enrolment | 130 |
| Start date | 2010-10 |
| Completion | 2012-09 |
Conditions
- Alcoholic Liver Disease
Interventions
- hepatitis, alcohol, probiotics
- alcohol, hepatitis, Placebo
Primary outcomes
- Liver Enzymes(ALT) — 7 days after probiotics
Blood analysis was performed using standard methodologies.
Countries
South Korea