Who is sponsoring NCT01497483?

NCT01497483 is sponsored by University of California, San Francisco.

What drugs are being tested in NCT01497483?

Interventions: Pravastatin alone, Pravastatin and Cyclosporine.

What is the status of NCT01497483?

NCT01497483 is currently COMPLETED.

Last reviewed 2015-01-14 · How we verify

The Pharmacokinetic Interaction Between Pravastatin and Cyclosporine in Healthy Volunteers

NCT01497483 Phase 1 COMPLETED

This study will address the following question: Does cyclosporine affect the pharmacokinetics of pravastatin in healthy volunteers? Studies have shown that cyclosporine inhibits the organic anion transporter required for pravastatin transport into the liver, thus increasing pravastatin levels in the blood. The investigators hypothesize that this inhibition will vary among people based on genetic differences. This knowledge is important to help develop safer and more effective drug therapy with reduced side effects.

Details

Lead sponsor	University of California, San Francisco
Phase	Phase 1
Status	COMPLETED
Enrolment	21
Start date	2011-12
Completion	2013-12

Conditions

Healthy

Interventions

Pravastatin alone
Pravastatin and Cyclosporine

Primary outcomes

Composite of Pharmacokinetics of co-administration of pravastatin & cyclosporine in healthy volunteers — 24 hours

Countries

United States