Effect of an Antioxidant and Anti-inflammatory Dietary Supplement Pack on the Adverse Physiological Actions Associated With Acute PM2.5 Exposure

NCT01488656 NA COMPLETED

This study will determine if a comprehensive antioxidant/anti-inflammatory dietary supplement pack can offer protection against a decline in lung function and increase in inflammation and oxidative stress following acute exposure to particulate matter air pollution with a diameter \<2.5 µm (PM2.5). The investigators hypothesis is a follows: Compared to an appropriate control, supplementation with a comprehensive antioxidant/anti-inflammatory dietary supplement pack for 18 weeks will: 1) reduce the decline in lung function following acute exposure to naturally occurring elevations in PM2.5 levels as measured by exhaled nitric oxide levels and forced vital lung capacity; and 2) reduce changes in pro-inflammatory cytokines following acute exposure to naturally occurring elevations in PM2.5 levels as measured by plasma levels of C-reactive protein.

Details

Lead sponsor	Utah State University
Phase	NA
Status	COMPLETED
Enrolment	66
Start date	2011-11
Completion	2012-06

Conditions

• Inflammation

Interventions

• Placebo
• Antioxidant, anti-inflammatory dietary supplement

Primary outcomes

• Forced vital lung capacity (FVC) — Six times over 3 months to coincide with high and low PM2.5 exposure