NCT01488448 is a NA clinical trial of 3% sodium chloride in Bronchiolitis, sponsored by Montefiore Medical Center.

Who is sponsoring NCT01488448?

NCT01488448 is sponsored by Montefiore Medical Center.

What drugs are being tested in NCT01488448?

Interventions in NCT01488448: 3% sodium chloride, 0.9% sodium chloride.

What condition does NCT01488448 study?

NCT01488448 studies Bronchiolitis.

Is NCT01488448 still recruiting?

NCT01488448 is currently completed. Last updated 31 January 2017.

Are results published for NCT01488448?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2017-01-31 · How we verify

NCT01488448

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A Double-Blind, Controlled, Randomized Clinical Trial of Nebulized Hypertonic Saline for Hospitalized Infants With Viral Bronchiolitis

Completed NA Results posted Last updated 31 January 2017

What this trial tests

NA trial testing 3% sodium chloride in Bronchiolitis in 227 participants. Completed in 1 August 2015.

Timeline

1 November 2011

Primary endpoint
1 July 2014

1 August 2015

Quick facts

Lead sponsor	Montefiore Medical Center
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	227
Start date	1 November 2011
Primary completion	1 July 2014
Estimated completion	1 August 2015
Sites	1 location across United States

Drugs / interventions tested

3% sodium chloride — full drug profile →
0.9% sodium chloride

Conditions studied

Bronchiolitis — all drugs for Bronchiolitis →

Sponsor

Montefiore Medical Center

Who can join

Under 12 Months, any sex, with Bronchiolitis. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Length of Stay in the Study-LOS--Intention to Treat Analysis
Time frame: Time of first study treatment until time of discharge
Length of stay will be defined by the duration between the time of first study treatment to the time a discharge order is placed. Alternatively, if a patient remains inpatient for other, non-bronchiolitis related reasons (i.e. social reasons, etc.) the time a patient could be discharged from the standpoint of bronchiolitis as documented by the attending, will be used.
Length of Stay in the Study-LOS by Per Protocol Analysis
Time frame: Time of first study treatment until time of discharge
Length of stay will be defined by the duration between the time of first study treatment to the time a discharge order is placed. Alternatively, if a patient remains inpatient for other, non-bronchiolitis related reasons (i.e. social reasons, etc.) the time a patient could be discharged from the standpoint of bronchiolitis as documented by the attending, will be used.

Sponsor's own description

The purpose of this study is to determine if nebulized hypertonic saline (or extra salty water mist) helps infants less than 12 months old hospitalized with bronchiolitis (or bad chest colds) get better enough to be discharged from the hospital sooner than those infants given nebulized normal saline (or regular salty water mist).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Nebulised hypertonic saline solution for acute bronchiolitis in infants.
Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP. · · 2017 · cited 48× · PMID 29265171 · DOI 10.1002/14651858.cd006458.pub4

Verify or expand the search:

Other recruiting trials for Bronchiolitis

Currently open trials in the same condition.

NCT07251972 — Comparison of Two Methods of Immunoprophylaxis Against RSV in Term Newborns · active not recruiting
NCT06862895 — Effect of Chest Physiotherapy on Clinical Outcome of Infants With Bronchiolitis · NA · recruiting
NCT06842238 — Descriptive Study of the Initial Management of Young Children With Moderate Acute BRONCHiotitis With Home Hospitalisatio · recruiting
NCT06425107 — Point-of-Care Lung Ultrasound for Prognosis in Critically Ill Infants With Acute Lower Respiratory Tract Infection · recruiting
NCT06108648 — Efficacy of Lavender Essential Oil Chest Wraps in Infants With Bronchiolitis · Phase 4 · recruiting

Other Montefiore Medical Center trials

Trials by the same sponsor.

NCT07224061 — Promoting Asthma Management Guidelines With Technology-Based Intervention and Care Coordination in Clinics and Schools · NA · not yet recruiting
NCT06775886 — Effect of Personalized Accelerated Pacing in Symptomatic Patients With Non-Obstructive Hypertrophic Cardiomyopathy · NA · terminated
NCT06919094 — A Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults · NA · recruiting
NCT07076069 — The Effect of Multimodal Pain Regimen on Use of Narcotics After Rotator Cuff Tear Repair · Phase 4 · recruiting
NCT07037940 — Physician Response Evaluation With Contextual Insights vs. Standard Engines - Artificial Intelligence RAG vs LLM Clinica · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01488448 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Montefiore Medical Center
Last refreshed: 31 January 2017

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01488448.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing