Effects of Preoperative Sublingual Misoprostol on Uterine Tone During Isoflurane Anaesthesia for Caesarean Section

NCT01466530 Phase 2 COMPLETED

Misoprostol would reduce the uterine bleeding after caesarean delivery, without harmful effects on either mother or baby. The investigators postulated that the use of sublingual misoprostol during isoflurane anaesthesia for uncomplicated caesarean delivery would reduce maternal haemorrhage, uterine atonic effects, and the need for additional uterotonic agents, without harmful effects on either mother or baby. Therefore, the present study was designed to evaluate the effects of preoperative sublingual misoprostol on maternal blood loss, uterine tone, the need for additional oxytocin and neonatal outcome after elective caesarean delivery under isoflurane anaesthesia.

Details

Lead sponsor	Mansoura University
Phase	Phase 2
Status	COMPLETED
Enrolment	366
Start date	2006-01
Completion	2011-09

Conditions

• Pregnancy
• Cesarean Delivery

Interventions

• Placebo
• Misoprostol

Primary outcomes

• estimated blood loss after caesarean delivery — up to 24 hours
  estimated blood loss (EBL) = pregnancy blood volume (ml) (EBV) x \[preoperative haematocrit - postoperative haematocrit\] / preoperative haematocrit, where EBV measured as shown in the following formula; (0.75 x {\[maternal height (inches) x 50\] + \[maternal weight in pounds x 25\]})

Countries

Egypt