The Effects of Intravenous Heme Arginate on Functional Magnetic Resonance Imaging During Ischemia

NCT01461512 Phase 2 UNKNOWN

Ischemia reperfusion injury may be attenuated by HO-1 induction. Heme arginate showed protective effects during prolonged ischemia in animal studies. Functional blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) shall evaluate the effects of HO-1 induction during short-time ischemia in skeletal muscle of healthy subjects.

Details

Lead sponsor	MWolzt
Phase	Phase 2
Status	UNKNOWN
Enrolment	16
Start date	2009-01
Completion	2011-12

Conditions

• Ischemia-reperfusion Injury

Interventions

• heme arginate administration
• Placebo administration

Primary outcomes

• BOLD MRI signal — 2 minutes prior to ischemia till 25 minutes after ischemia
  functional MRI assessment of blood oxygen level dependent signal strength
• Serum markers of myocellular injury — 24 hours after ischemia
  (myoglobin, creatine-kinase)

Countries

Austria