NCT01399385

New Heart Imaging Techniques to Evaluate Possible Heart Disease

Recruiting now NA Last updated 14 April 2026

What this trial tests

NA trial testing MR Imaging Techniques - 1 in Healthy in 4,000 participants. Currently enrolling.

Timeline

6 July 2011

Primary endpoint
6 November 2028

5 November 2030

Quick facts

Lead sponsor	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	non randomized
Design	sequential
Masking	none
Primary purpose	basic science
Enrollment	4,000
Start date	6 July 2011
Primary completion	6 November 2028
Estimated completion	5 November 2030
Sites	1 location across United States

Drugs / interventions tested

• MR Imaging Techniques - 1
• MR Imaging Techniques - 2
• MR Imaging Techniques - 3
• MR Imaging Techniques - 4

Conditions studied

• Healthy — all drugs for Healthy →
• Obesity — all drugs for Obesity →
• Diabetes — all drugs for Diabetes →
• Healthy Volunteers — all drugs for Healthy Volunteers →

Sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Who can join

Adults 18 to 100, any sex, with Healthy or Obesity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background:

\- Imaging tests, such as magnetic resonance imaging (MRI), can provide information about heart and blood vessels. The tests let doctors can see the amount of blood vessel narrowing and vessel wall thickness. This information may help diagnose and treat heart disease and other conditions that lead to heart attacks. Better MRI methods are needed to improve heart disease diagnosis, especially by avoiding the use of radiation. Researchers are testing new techniques to improve the quality of heart MRI, compared with more complex studies like catheterization or angiography.

Objectives:

\- To compare heart MRI techniques with other tests used to diagnose heart disease.

Eligibility:

\- People at least 18 years of age who either have or may have heart disease, or are healthy volunteers.

Design:

* Participants will be screened with a physical exam, medical history, and blood tests.
* They will have an angiography to study the inside of blood vessels. This test is an x-ray study of the blood vessels. It will be done either separately or as part of a set of tests to diagnose possible heart disease.
* Participants will have at least one and up to five MRI scans. The scans will involve different methods of studying the heart and blood vessels. Participants may also have a computed tomography scan to confirm the findings of an MRI scan.
* No treatment will be provided as part of this protocol....

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Hypercortisolism is associated with increased coronary arterial atherosclerosis: analysis of noninvasive coronary angiography using multidetector computerized tomography.
   Neary NM, Booker OJ, Abel BS, Matta JR, et al · · 2013 · cited 59× · PMID 23559084 · DOI 10.1210/jc.2012-3754
2. Automatic Coronary Wall and Atherosclerotic Plaque Segmentation from 3D Coronary CT Angiography.
   Ghanem AM, Hamimi AH, Matta JR, Carass A, et al · · 2019 · cited 22× · PMID 30631101 · DOI 10.1038/s41598-018-37168-4
3. Proton MR Spectroscopy Measurements of White and Brown Adipose Tissue in Healthy Humans: Relaxation Parameters and Unsaturated Fatty Acids.
   Ouwerkerk R, Hamimi A, Matta J, Abd-Elmoniem KZ, et al · · 2021 · cited 19× · PMID 33724063 · DOI 10.1148/radiol.2021202676
4. Coronary calcification in adults with Turner syndrome.
   Schoepp M, Hannah-Shmouni F, Matta J, Ghanem AM, et al · · 2018 · cited 18× · PMID 29176683 · DOI 10.1038/gim.2017.149
5. Coronary atherosclerosis and dilation in hyper IgE syndrome patients: Depiction by magnetic resonance vessel wall imaging and pathological correlation.
   Abd-Elmoniem KZ, Ramos N, Yazdani SK, Ghanem AM, et al · · 2017 · cited 17× · PMID 28167354 · DOI 10.1016/j.atherosclerosis.2017.01.022
6. Endothelial Dysfunction in Youth-Onset Type 2 Diabetes: A Clinical Translational Study.
   Abd-Elmoniem KZ, Edwan JH, Dietsche KB, Villalobos-Perez A, et al · · 2024 · cited 12× · PMID 39069898 · DOI 10.1161/circresaha.124.324272
7. Sexual Dimorphism of Coronary Artery Disease in a Low- and Intermediate-Risk Asymptomatic Population: Association with Coronary Vessel Wall Thickness at MRI in Women.
   Ghanem AM, Matta JR, Elgarf R, Hamimi A, et al · · 2019 · cited 7× · PMID 32076665 · DOI 10.1148/ryct.2019180007
8. Association of Coronary Wall Thickening and Diminished Diastolic Function in Asymptomatic, Low Cardiovascular Disease-Risk Persons Living with HIV.
   Abd-Elmoniem KZ, Ishaq H, Purdy J, Matta J, et al · · 2024 · cited 3× · PMID 38573125 · DOI 10.1148/ryct.230102