Effect of High Dose Selenium on Inflammation and Neurological Outcome After Cardiac Arrest: A Randomized, Double Blind Placebo Controlled Phase 2a Study (SCPR)

NCT01390506 Phase 2 WITHDRAWN

After cardiac arrest and successful resuscitation it can happen that the brain function of a patient is impaired because the brain was without oxygen for a prolonged period of time. Several strategies have been studied to improve brain function after cardiac arrest. Cooling of the patients is routinely used today. The trace element selenium has several biological functions and is important for defense mechanisms against oxidative stress, which occurs after cardiac arrest and successful resuscitation. critically ill patients have low selenium blood levels. Therefore the investigators hypothesize that giving selenium after cardiac arrest and successful resuscitation might improve brain function.

Details

Lead sponsor	Medical University of Graz
Phase	Phase 2
Status	WITHDRAWN
Start date	2017-01
Completion	2019-07

Conditions

• Cardiac Arrest

Interventions

• Sodium-selenite
• Placebo

Primary outcomes

• neuron specific enolase — 72 hours
  Reduction of neuron specific enolase below by more than 4.4 µg/l at 72 hours after admission to the hospital

Countries

Austria