Effects of Oral Citrulline on Protein Metabolism in Patients With Intestinal Failure : a Prospective, Randomized, Double-blind, Cross-over Study (CITRUGRELE 2)

NCT01386034 Phase 3 COMPLETED

The specific aim of this study is to determine whether oral citrulline administration enhances whole body protein synthesis in patients with intestinal failure. Protein metabolism will be assessed using an intravenous infusion of stable isotope labeled leucine. The investigators hypothesize that citrulline supplementation will decrease leucine oxidation without altering proteolysis, and consequently stimulate protein synthesis.

Details

Lead sponsor	Nantes University Hospital
Phase	Phase 3
Status	COMPLETED
Enrolment	11
Start date	2012-07
Completion	2015-07

Conditions

• Intestinal Failure

Interventions

• Citrulline and placebo

Primary outcomes

• whole body protein synthesis
  To determine whether oral citrulline administration enhances whole body protein synthesis in patients with intestinal insufficiency, as measured using an intravenous infusion of stable isotope labelled leucine.

Countries

France