Ex Vivo Effect of Fragments and Modified Forms of Surfactant Protein D on Pulmonary Immune Cells Derived From Bronchoalveolar Lavage After Segmental Allergen Challenge in Patients With Asthma and Pilot Study to Assess Local Inflammation Induced by Segmental Allergen Challenge by Magnetic Resonance Imaging

NCT01378624 NA COMPLETED

Ex vivo effect of fragments and modified forms of surfactant protein D on pulmonary immune cells derived from bronchoalveolar lavage after segmental allergen challenge in patients with asthma and pilot study to assess local inflammation induced by segmental allergen challenge by magnetic resonance imaging.

Details

Lead sponsor	Fraunhofer-Institute of Toxicology and Experimental Medicine
Phase	NA
Status	COMPLETED
Enrolment	15
Start date	2011-06
Completion	2012-10

Conditions

• Mild Intermittent Asthma (Gina 1)

Interventions

• Bronchoscopy

Primary outcomes

• Change in local inflammation — Baseline, 6 and 24 hours post segmental allergen challenge
  Magnetic resonance imaging to assess local inflammation prior to as well as 6 h and 24 h after segmental allergen challenge
• Change of numbers of matured dendritic cells — Baseline and 24 h post segmental allergen challenge
  Change of numbers of matured dendritic cells in vitro in the absence and presence of surfactant protein D.

Countries

Germany