COX-2 Inhibitor Versus Glucocorticoid Versus Both Combined

NCT01361789 Phase 4 COMPLETED

Recent studies on molar surgery have shown that a combination of a glucocorticoid and NSAID or COX-2 selective inhibitor gives better pain relief than either of the drugs used separately. The investigators group has also shown that adding dexamethasone on top of a regimen of paracetamol, NSAID and local anesthesia resulted in 45% painfree patients at rest after ambulatory breast cancer surgery. The goal of this study is to test the NSAID + glucocorticoid concept in ACl repair. The investigators want to evaluate whether a selective COX-2 selective inhibitor or a glucocorticoid or a combination of both drugs, as part of a multimodal analgesic regime, can provide improved pain relief and shorter hospital stay in patients undergoing outpatient ACL surgery.

Details

Lead sponsor	Asker & Baerum Hospital
Phase	Phase 4
Status	COMPLETED
Enrolment	93
Start date	2004-01
Completion	2009-12

Conditions

• Rupture of Anterior Cruciate Ligament

Interventions

• parecoxib, valdecoxib, etoricoxib
• Dexamethasone
• parecoxib, valdecoxib, parecoxib and dexamethasone

Primary outcomes

• Postoperative VAS score at rest 24 hours after surgery — 24 hours

Countries

Norway