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NCT01356680
HD17 for Intermediate Stage Hodgkin Lymphoma
Completed
Phase 3
Last updated 6 April 2020
What this trial tests
Phase 3 trial testing BEACOPPescalated (Bleomycin, Etoposide, Adriamycin, Cyclophosphamide, Vincristine, Procarbazine, Prednisone) in Hodgkin Lymphoma in 1,100 participants. Completed in 23 March 2020.
Timeline
13 January 2012
Primary endpoint
21 March 2020
21 March 2020
23 March 2020
Quick facts
| Lead sponsor | University of Cologne |
|---|---|
| Phase | Phase 3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 1,100 |
| Start date | 13 January 2012 |
| Primary completion | 21 March 2020 |
| Estimated completion | 23 March 2020 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- BEACOPPescalated (Bleomycin, Etoposide, Adriamycin, Cyclophosphamide, Vincristine, Procarbazine, Prednisone)
- ABVD (Adriamycin, Bleomycin, Vinblastine, Dacarbazine) — full drug profile →
- 30Gy IF-RT (Involved-Field Radiotherapy)
- 30Gy IN-RT (Involved-Node Radiotherapy)
Conditions studied
- Hodgkin Lymphoma — all drugs for Hodgkin Lymphoma →
Sponsor
University of Cologne
Who can join
Adults 18 to 60, any sex, with Hodgkin Lymphoma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study is designed to test the non-inferiority of the experimental arm compared to the standard arm in terms of progression free survival (PFS).
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
-
PET-guided omission of radiotherapy in early-stage unfavourable Hodgkin lymphoma (GHSG HD17): a multicentre, open-label, randomised, phase 3 trial.
Borchmann P, Plütschow A, Kobe C, Greil R, et al · · 2021 · cited 96× · PMID 33539742 · DOI 10.1016/s1470-2045(20)30601-x -
Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphoma.
Thurner L, Hartmann S, Fadle N, Regitz E, et al · · 2020 · cited 40× · PMID 32424289 · DOI 10.1038/s41467-020-16375-6 -
Value of bone marrow biopsy in Hodgkin lymphoma patients staged by FDG PET: results from the German Hodgkin Study Group trials HD16, HD17, and HD18.
Voltin CA, Goergen H, Baues C, Fuchs M, et al · · 2018 · cited 35× · PMID 30010775 · DOI 10.1093/annonc/mdy250 -
The role of FDG-PET in defining prognosis of Hodgkin lymphoma for early-stage disease.
Evens AM, Kostakoglu L. · · 2014 · cited 24× · PMID 25428223 · DOI 10.1182/blood-2014-05-577627 -
Chemotherapy alone versus chemotherapy plus radiotherapy for adults with early stage Hodgkin lymphoma.
Blank O, von Tresckow B, Monsef I, Specht L, et al · · 2017 · cited 13× · PMID 28447341 · DOI 10.1002/14651858.cd007110.pub3 -
Prognostic value of baseline metabolic tumor volume (MTV) for forecasting chemotherapy outcome in early-stage unfavorable Hodgkin lymphoma: Data from the phase III HD17 trial.
van Heek L, Weindler J, Gorniak C, Kaul H, et al · · 2023 · cited 8× · PMID 37644732 · DOI 10.1111/ejh.14093 -
Radiation Therapy in the German Hodgkin Study Group HD 16 and HD 17 Trials: Quality Assurance and Dosimetric Analysis for Hodgkin Lymphoma in the Modern Era.
Oertel M, Hering D, Nacke N, Kittel C, et al · · 2023 · cited 8× · PMID 36896214 · DOI 10.1016/j.adro.2022.101169 -
The evolving role of response-adapted PET imaging in Hodgkin lymphoma.
Coyle M, Kostakoglu L, Evens AM. · · 2016 · cited 8× · PMID 27054026 · DOI 10.1177/2040620715625615
Verify or expand the search:
- PubMed search for NCT01356680
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
Data sources for this page
- Trial protocol + status: ClinicalTrials.gov NCT01356680 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Cologne
- Last refreshed: 6 April 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01356680.
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