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Enhancing Exposure Therapy for PTSD: Virtual Reality and Imaginal Exposure With a Cognitive Enhancer
The purpose of this study is to test the differences between four active treatment conditions for combat-related Post Traumatic Stress Disorder (PTSD): virtual reality exposure therapy (VRE) or prolonged imaginal exposure therapy (PE), both with DCS or placebo, as well as to examine predictors for PTSD and response to treatment in active duty military personnel, veterans, and civilians who served in Iraq and Afghanistan.
Details
| Lead sponsor | Weill Medical College of Cornell University |
|---|---|
| Phase | Phase 3 |
| Status | COMPLETED |
| Enrolment | 192 |
| Start date | 2011-05 |
| Completion | 2018-09 |
Conditions
- Post Traumatic Stress Disorder
Interventions
- DCS (D-Cycloserine ) + Prolonged Imaginal Exposure
- DCS (D-Cycloserine ) + Virtual Reality Exposure
- Placebo + Prolonged Imaginal Exposure
- Placebo (sugar pill) + Virtual Reality Exposure
Primary outcomes
- CAPS-IV at the End of Treatment — after weekly treatment session 9 (at posttreatment assessment)
Clinician Administered PTSD Scale (CAPS) for the DSM-IV \[34\]. The CAPS-IV is a structured clinical interview designed to assess the 17 DSM-IV PTSD symptoms. CAPS-IV provides categorical ratings of diagnostic status as well as a quantitative index of symptom severity. The CAPS total severity score is based on response to the 17 items that assess the frequency and intensity of current PTSD symptoms. Symptom severity is assessed separately for past month and past week time frames. CAPS-IV range is 0-136, higher scores mean a worse outcome.
Countries
United States