Effect of the Direct Renin Inhibitor Aliskiren on Endothelial Function and Arterial Stiffness in Diabetic Subjects

NCT01349114 Phase 4 TERMINATED Results posted

The study will evaluate the effects of the direct renin inhibitor, aliskiren, on flow-mediated dilation of the brachial artery and on central aortic pressure in diabetic patients with pre-hypertension or Stage 1 hypertension.

Details

Lead sponsor	University of Alabama at Birmingham
Phase	Phase 4
Status	TERMINATED
Enrolment	21
Start date	2011-06
Completion	2012-01

Conditions

• Diabetes
• Pre-hypertension
• Hypertension

Interventions

• aliskiren 300 mg once daily
• Placebo/sugar pill

Primary outcomes

• Change in Flow-mediated Dilation — Baseline to 3 months
  Flow-mediated dilation of the brachial artery assessed by ultrasound to evaluate improvement of arterial functioning by % of dilation after non-invasive occlusion

Countries

United States