NCT01345643: WCPTS

A Randomized Controlled Clinical Trial of Transfusion Under the Guidance of West-China Perioperative Transfusion Score(WCPTS）for Massive Hemorrhagic Surgery

Completed NA Last updated 3 May 2024

What this trial tests

NA trial testing Maintenance of hemoglobin level not less than 10g/dL in Transfusion Related Complications in 190 participants. Completed in 1 February 2014.

Timeline

1 February 2011

Primary endpoint
1 June 2012

1 February 2014

Quick facts

Lead sponsor	Ren Liao
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	190
Start date	1 February 2011
Primary completion	1 June 2012
Estimated completion	1 February 2014
Sites	1 location across China

Drugs / interventions tested

• Maintenance of hemoglobin level not less than 10g/dL
• Transfusion trigger based on WCPTS

Conditions studied

• Transfusion Related Complications — all drugs for Transfusion Related Complications →

Sponsor

Ren Liao

Who can join

Adults 15 to 70, any sex, with Transfusion Related Complications. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

• Proportion of patients who received red blood cells transfusion
  Time frame: Up to 12 weeks.
  Proportion of patients who received red blood cells transfusion (Patients received red cells transfusion/ total number of the patients)
• Transfusion volume of red blood cells
  Time frame: Up to 12 weeks.
  Volume of red blood cells transfused to the patients (units)

Sponsor's own description

Guidelines for blood transfusion have been issued for years. According to these guidelines, red blood cells (RBCs) transfusion should be given when the hemoglobin level is less than 6g/dL or 7g/dL and is unnecessary when the level is more than 10g/dL. However, in all the guidelines, the determination of whether RBCs should be administered when the hemoglobin level is in the range of 7\~10g/dL is based on the judgment from anesthesiologists or surgeons. Index of transfusion trigger for patients with hemoglobin level between 7/dL and 10g/dL is necessary and important in clinical practice. Based on the aim of blood transfusion that maintain the balance of oxygen supply and oxygen consumption, the investigators hypothesize that index of transfusion trigger for patients with hemoglobin level between 7/dL and 10g/dL could be calculated by their history about heart and blood pressure, and routine monitoring parameters including pulse oximetry, temperature, and the use of vasoactive medications. To verify this hypothesis, the investigators present West China Perioperative Transfusion Score (WCPTS) for the trigger of transfusion according to the patient's history and monitoring parameters, and the investigators design a randomized controlled clinical trial to test this score.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.