Who is sponsoring NCT01340001?

NCT01340001 is sponsored by University Hospital, Rouen.

What drugs are being tested in NCT01340001?

Interventions in NCT01340001: Electrical stimulation of the nucleus basalis of Meynert.

What condition does NCT01340001 study?

NCT01340001 studies Dementia With Lewy Bodies.

Is NCT01340001 still recruiting?

NCT01340001 is currently completed. Last updated 30 April 2018.

Last reviewed 2018-04-30 · How we verify

NCT01340001: DEMENSTIM

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effects of Nucleus Basalis of Meynert Stimulation on Cognitive Disorders in Dementia With Lewy Bodies

Completed NA Last updated 30 April 2018

What this trial tests

NA trial testing Electrical stimulation of the nucleus basalis of Meynert in Dementia With Lewy Bodies in 6 participants. Completed in 22 December 2017.

Timeline

24 October 2012

Primary endpoint
22 December 2017

22 December 2017

Quick facts

Lead sponsor	University Hospital, Rouen
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	6
Start date	24 October 2012
Primary completion	22 December 2017
Estimated completion	22 December 2017
Sites	1 location across France

Drugs / interventions tested

Electrical stimulation of the nucleus basalis of Meynert

Conditions studied

Dementia With Lewy Bodies — all drugs for Dementia With Lewy Bodies →

Sponsor

University Hospital, Rouen

Who can join

Adults 18 to 75, any sex, with Dementia With Lewy Bodies. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Deep brain stimulation has been developed as a substitute for the classical lesioning methods previously used in stereotactic and functional neurosurgery. Recent, anecdotal cases reports suggested that electrical stimulation of the cholinergic output of the Nucleus Basalis of Meynert (NBM) may improve cognitive performances, especially the memory tasks. The present study aims to assess the effect of bilateral electrical stimulation of the NBM on the mnesic performance \[assessed by the sum of the three free recalls of the Free and Cued Selective Recall Reminding Test (FCSRT)\] in patients diagnosed with probable, moderate, Dementia with Lewy Bodies.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Challenges and opportunities for improving the landscape for Lewy body dementia clinical trials.
Goldman JG, Forsberg LK, Boeve BF, Armstrong MJ, et al · · 2020 · cited 44× · PMID 33121510 · DOI 10.1186/s13195-020-00703-5
Nucleus Basalis of Meynert Stimulation for Lewy Body Dementia: A Phase I Randomized Clinical Trial.
Maltête D, Wallon D, Bourilhon J, Lefaucheur R, et al · · 2021 · cited 24× · PMID 33199437 · DOI 10.1212/wnl.0000000000011227
Deep Brain Stimulation for the Management of Refractory Neurological Disorders: A Comprehensive Review.
Rissardo JP, Vora NM, Tariq I, Mujtaba A, et al · · 2023 · cited 17× · PMID 38004040 · DOI 10.3390/medicina59111991

Verify or expand the search:

Other recruiting trials for Dementia With Lewy Bodies

Currently open trials in the same condition.

NCT06357195 — DIAMOND-Lewy Guidelines for Antipsychotic Use in Older Patients · active not recruiting
NCT06389032 — PERSEVERE: Peer Mentor Support and Caregiver Education in Lewy Body Dementia · NA · active not recruiting
NCT06467461 — Identification of Prodromal Neurodegeneration in Serotonergic-Induced REM Sleep Behavior Disorder · NA · recruiting
NCT06005935 — Environmental and Reproductive Health Risk for Lewy Body Dementia · active not recruiting
NCT05460143 — Optical Neuroimaging and Cognition · recruiting

Other University Hospital, Rouen trials

Trials by the same sponsor.

NCT07441564 — Evaluation of the Efficacy of Ischemic Preconditioning to Protect Against Acute Kidney Injury After Open Surgery for Jux · NA · not yet recruiting
NCT07535944 — Prospective Exploration of Vascular Complications Associated With the Use of Immune Checkpoint Inhibitors · not yet recruiting
NCT07464184 — Evolution of Hypoxic Burden and Sympathetic/Parasympathetic Balance in Patients With Pulmonary Hypertension · NA · not yet recruiting
NCT07359885 — Prediction of Postoperative Pulmonary Complications in Thoracic Surgery · not yet recruiting
NCT07247500 — Impact of Reventilation After One-Lung Ventilation in Thoracic Surgery (OLVREEXP) · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01340001 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Rouen
Last refreshed: 30 April 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01340001.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing