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The Topical Niacin Skin Flush Test: A Means for Longitudinal Monitoring of Two Different Biological Subgroups of Patients With First Episode Psychosis
The purpose of this study is to gather normative data from healthy adults and to determine a sensitive and specific cut-off value for responders and non-responders to the Niacin Skin Flush Test in a sample of first episode psychosis patients.
Details
| Lead sponsor | Nova Scotia Health Authority |
|---|---|
| Status | TERMINATED |
| Enrolment | 107 |
| Start date | 2011-12 |
| Completion | 2016-07 |
Conditions
- Psychotic Disorders
- Schizophrenia
Interventions
- skin test
Primary outcomes
- change in visual rating of skin response (redness and oedema) — ratings made at 3, 6, 9 and 12 minutes after application of methyl nicotinate
A 7-point visual rating scale, previously tested for reliability (Kerr 2008), to visually rate the skin response to aqueous methyl nicotinate (niacin) with respect to both redness and oedema as a function of increasing niacin concentrations.Ratings will be acquired every three minutes over a 12-minute period starting at the time of solution application.
Countries
Canada