Who is sponsoring NCT01319552?

NCT01319552 is sponsored by Columbia University.

What condition does NCT01319552 study?

NCT01319552 studies Iron, Abnormal Blood Level, Other Abnormal Blood Chemistry.

What drugs are being tested in NCT01319552?

Interventions: Fresh transfusion, Old transfusion.

What is the status of NCT01319552?

NCT01319552 is currently COMPLETED.

Last reviewed 2015-05-15 · How we verify

Immunomodulatory Properties of Fresh Versus Stored Packed Red Blood Cells for Transfusion

NCT01319552 NA COMPLETED Results posted

Packed red blood cell units destined for transfusion can be stored for up to 42 days prior to transfusion based on Food and Drug Administration (FDA) guidelines. Recent studies suggest that certain patients transfused with blood stored for longer duration have poorer outcomes than patients transfused fresher blood. The investigators' hypothesis is that the delivery of an immediate and substantial load of hemoglobin-associated iron from a stored unit of blood leads to changes that explain the differences in outcome between patients transfused old versus fresh blood. The investigators propose to test this hypothesis in humans by transfusing an individual's own blood, both fresh and after storage, and comparing levels of various outcome measures.

Details

Lead sponsor	Columbia University
Phase	NA
Status	COMPLETED
Enrolment	14
Start date	2008-12
Completion	2010-10

Conditions

Iron, Abnormal Blood Level
Other Abnormal Blood Chemistry

Interventions

Fresh transfusion
Old transfusion

Primary outcomes

Measure of Non-transferrin-bound Iron — four hours after transfusion
Comparison of increase in non-transferrin-bound iron for each participant between his or her "fresh" and "old" blood transfusion four hours after transfusion.

Countries

United States