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Serological and Non-invasive Evaluation of Endothelial Function in Patients With Pulmonary Arterial Hypertension
The objectives of the current study are to identify and evaluate new prognostic non-invasive and serological markers in patients with pulmonary hypertension. The focus will be on L-arginine metabolism and to clarify its influence on endothelial function.
Details
| Lead sponsor | Universitätsklinikum Hamburg-Eppendorf |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 90 |
| Start date | 2010-10 |
| Completion | 2016-07 |
Conditions
- Hypertension, Pulmonary
- Pulmonary Arterial Hypertension
- Pathophysiology
- Genetics
Interventions
- EndoPAT measurement
- Blood Test
Primary outcomes
- Differences of endothelial function regarding disease class and severity — 0, 3, 6, 9 and 12 months
1. Quantification of L-arginine metabolites in whole blood 2. PAT-Ratio as non-invasively assessed endothelial function by EndoPAT2000-Device (Itamar Medical Ltd., Caesarea, Israel) 0 months = Time of Inclusion
Countries
Germany