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Effects of Urocortins on Forearm Arterial Blood Flow in Healthy Volunteers
Impairment of the heart's pumping capacity (heart failure) remains a major clinical problem with a poor prognosis and the search for novel treatments remains an important area of research. Urocortins are proteins that appear to increase blood flow and heart pumping activity. There has been particular interest in the role of Urocortins 2 \& 3 (subtypes of Urocortins) in heart failure. In this study, we will examine the pharmacokinetics and pharmacodynamics (in particular the onset-offset of action and reproducibility of vasodilator effects) of Urocortins 2 \& 3 on forearm arterial blood flow healthy volunteers. Utilising the well-established technique of 'forearm venous occlusion plethysmography', we will be able to focus on the local effects of urocortins on arterial blood flow in forearm vessels, without affecting this system in the body as a whole.
Details
| Lead sponsor | University of Edinburgh |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 12 |
| Start date | 2011-02 |
| Completion | 2011-07 |
Conditions
- Cardiovascular Disease
- Heart Failure
Interventions
- Urocortin 2
- Urocortin 3
Primary outcomes
- Forearm blood flow — 3.5 hours
Difference in forearm blood flow in response to increasing doses of Urocortin 2 and Urocortin 3 in the presence and absence of saline washout between doses
Countries
United Kingdom