Last reviewed · How we verify
NCT01293214
Vascularized Composite Allotransplantation for Multiple Extremity Amputations
NA trial testing Limb transplantation in Limb Amputation in 10 participants. Currently enrolling.
31 December 2026
Quick facts
| Lead sponsor | Brigham and Women's Hospital |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 10 |
| Start date | 1 February 2010 |
| Primary completion | 31 December 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Limb transplantation
Conditions studied
- Limb Amputation — all drugs for Limb Amputation →
- Extremity Amputation — all drugs for Extremity Amputation →
Sponsor
Brigham and Women's Hospital
Who can join
Adults 18 to 60, any sex, with Limb Amputation or Extremity Amputation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Limb transplantation surgery is the transfer of one or more limbs from a deceased human donor to a patient with single or multiple limb amputation. Hand transplantation is an innovative reconstructive procedure that has the potential to significantly improve the lives of hand amputees. The purpose of this study is to develop the best practices for multiple limb transplantation that will improve the outcomes of future limb transplant recipients.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
T cell-attracting CCL18 chemokine is a dominant rejection signal during limb transplantation.
Borges TJ, Abarzua P, Gassen RB, Kollar B, et al · · 2022 · cited 11× · PMID 35492875 · DOI 10.1016/j.xcrm.2022.100559 -
Human type 1 conventional dendritic cells contribute to skin transplant rejection.
Borges TJ, Lee CAA, Mucciarone K, Lima K, et al · · 2025 · cited 4× · PMID 40286910 · DOI 10.1016/j.ajt.2025.04.016 -
Upper extremity composite tissue allotransplantation imaging.
George E, Mitsouras D, Kumamaru KK, Shah N, et al · · 2013 · cited 2× · PMID 23943677
Verify or expand the search:
- PubMed search for NCT01293214
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT01293214 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Brigham and Women's Hospital
- Last refreshed: 5 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01293214.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing