Effect of Pre-operative Adjunctive Anti-VEGF on Growth Factors in Severe Proliferative Diabetic Retinopathy Requiring Surgical Management (PDR)

NCT01270542 NA COMPLETED Results posted

The purpose of this study is to determine the effect of anti-VEGF drug (Avastin) adminstration in eyes prior to surgical treatment for Traction retinal detachment (TRD) in patients with Proliferative Diabetic Retinopathy (PDR).

Details

Lead sponsor	University of Southern California
Phase	NA
Status	COMPLETED
Enrolment	20
Start date	2009-06
Completion	2012-07

Conditions

• Retinal Detachment
• Diabetic Retinopathy

Interventions

• Avastin (bevacizumab)
• Sham injection

Primary outcomes

• The Effect of an Anti-VEGF (Vascular Endothelial Growth Factor) Agent, Bevacizumab, on Levels of Vitreous and Aqueous Growth Factor Levels (pg/mL) in Eyes With Traction Retinal Detachment Due to PDR — 3 months after last surgery
  Comparison of vitreous VEGF levels (pg/mL) and aqueous VEGF (pg/mL) levels in bevacizumab and control groups.

Countries

United States