Who is sponsoring NCT01261065?

NCT01261065 is sponsored by Michael E. DeBakey VA Medical Center.

What condition does NCT01261065 study?

NCT01261065 studies Heart Failure, Cardiomyopathy.

What is the status of NCT01261065?

NCT01261065 is currently COMPLETED.

Last reviewed 2025-09-22 · How we verify

Mechanisms of Improvement With Beta-Blocker Treatment in Heart Failure

NCT01261065 Phase 4 COMPLETED

The overall hypothesis of this application is that the improvement in LV ejection performance following treatment with betablockers is due, at least in part, to improvement in intrinsic myocardial contractility.

Details

Lead sponsor	Michael E. DeBakey VA Medical Center
Phase	Phase 4
Status	COMPLETED
Enrolment	55
Start date	2001-12
Completion	2005-10

Conditions

Heart Failure
Cardiomyopathy

Interventions

carvedilol

Primary outcomes

Load independent measure of contractility: Left ventricular velocity of circumferential shortening to left ventricular end systolic stress ratio — 6 months
Mean velocity of circumferential fiber shortening (VCF) will be derived as = Left Ventricular Fractional shortening / Ejection Time.Left ventricular (LV) end-systolic stress will be calculated as = (\[1.35 × P × LV endsysolic diameter\]/(4 × LV posterior wall thickness in systole × (1+LV posterior wall thickness in systole /LV endsysolic diameter)))

Countries

United States