NCT01255150

Frequency of EGFR Mutations in Latinos/Hispanics With Non-Small Cell Lung Cancer

Completed Last updated 21 November 2019

What this trial tests

trial in Non-Small-Cell Lung Carcinoma in 15 participants. Completed in 29 April 2015.

Timeline

1 December 2010

29 April 2015

Quick facts

Lead sponsor	National Cancer Institute (NCI)
Status	Completed
Study type	OBSERVATIONAL
Enrollment	15
Start date	1 December 2010
Estimated completion	29 April 2015
Sites	12 locations across Peru, Mexico, Bolivia, Venezuela, United States

Conditions studied

• Non-Small-Cell Lung Carcinoma — all drugs for Non-Small-Cell Lung Carcinoma →

Sponsor

National Cancer Institute (NCI)

Who can join

Adults 2 to 100, any sex, with Non-Small-Cell Lung Carcinoma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background:

\- Research has shown that the Epidermal Growth Factor Receptor (EGFR) gene is an important target for personalized lung cancer treatment. Individuals who have mutations in the EGFR gene have better responses when treated with certain personalized or targeted therapies compared with conventional chemotherapy. These mutations are more frequent in females with lung cancer who have never smoked, and different ethnic groups have different levels of frequency of the mutations. Researchers are interested in collecting more information on EGFR genetic mutations in Hispanics/Latinos with lung cancer, comparing the frequency of these mutations in males and females and smokers and nonsmokers. This study may lead to better, more personalized care approaches for all individuals with lung cancer.

Objectives:

\- To study the frequency of Epidermal Growth Factor Receptor mutations in Hispanic/Latino individuals who have been diagnosed with non-small cell lung cancer.

Eligibility:

\- Hispanic or Latino individuals who have been diagnosed with non-small cell lung cancer and who have lung tissue from a previous biopsy or surgery available for research purposes.

Design:

* Participants will provide consent for researchers to examine lung tissue collected from a previous biopsy or surgery.
* Treatment will not be provided as part of this protocol.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. <i>EGFR</i> Mutations in Latinos From the United States and Latin America.
   Lopez-Chavez A, Thomas A, Evbuomwan MO, Xi L, et al · · 2016 · cited 16× · PMID 28717712 · DOI 10.1200/jgo.2015.002105