NCT01251900

BRCA Mutations in Latinas

Completed Last updated 14 April 2026

What this trial tests

trial in Breast Neoplasms in 266 participants. Completed.

Timeline

7 July 2011

Quick facts

Lead sponsor	National Cancer Institute (NCI)
Status	Completed
Study type	OBSERVATIONAL
Enrollment	266
Start date	7 July 2011
Sites	1 location across United States

Conditions studied

• Breast Neoplasms — all drugs for Breast Neoplasms →

Sponsor

National Cancer Institute (NCI)

Who can join

Adults 18 to 99, female only, with Breast Neoplasms. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background:

\- BRCA1 and BRCA2 gene mutations have been linked to a higher risk of developing breast cancer and other cancers, and may be associated with types of breast cancer that are more difficult to treat and more likely to recur. New cancer treatments are being developed specifically to treat individuals who have these gene mutations. However, more information is needed about the prevalence of these mutations in minority populations, including Hispanic/Latino populations. To study these populations, researchers are interested in collecting genetic material (DNA) and medical history information from Hispanic/Latino women who have been diagnosed with breast cancer.

Objectives:

\- To collect saliva samples and medical and family history information from Hispanic/Latino women with breast cancer.

Eligibility:

\- Hispanic/Latino women at least 18 years of age who have been diagnosed with breast cancer.

Design:

* Participants will complete a questionnaire with information about place of birth, languages spoken by parents and grandparents, and information about their breast cancer diagnosis.
* Participants will provide a saliva sample (2 to 3 tablespoons) for analysis.
* No treatment will be provided as part of this protocol....

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Germline pathogenic variants associated with triple-negative breast cancer in US Hispanic and Guatemalan women using hospital and community-based recruitment strategies.
   Godinez Paredes JM, Rodriguez I, Ren M, Orozco A, et al · · 2024 · cited 2× · PMID 38520597 · DOI 10.1007/s10549-024-07300-2