Who is sponsoring PCA-Gene?

PCA-Gene is sponsored by Fondazione IRCCS Policlinico San Matteo di Pavia.

What condition does PCA-Gene study?

PCA-Gene studies Anesthesia, Surgery.

What drugs are being tested in PCA-Gene?

Interventions: morphine chlorhydrate.

What is the status of PCA-Gene?

PCA-Gene is currently COMPLETED.

Last reviewed 2013-07-18 · How we verify

Association Between Clinical Effect of Morphine in Patients With PCA After Major Surgery and Pharmacogenetics: Prospective Observational Clinical Study. (PCA-Gene)

NCT01233752 COMPLETED

Identification of the genetic polymorphisms that could be correlated either with a better clinical response or with a major predisposition of patients to develop tolerance and/or side effects to the treatment with morphine.

Details

Lead sponsor	Fondazione IRCCS Policlinico San Matteo di Pavia
Status	COMPLETED
Enrolment	224
Start date	2010-07
Completion	2013-07

Conditions

Anesthesia
Surgery

Interventions

morphine chlorhydrate

Primary outcomes

Assessment of the medium morphine dose (mg/kg/die)in the two groups homozygous patients for the more frequent allele of the polymorphism A118G of OPRM1 gene; group B: both homozygous and heterozygous patients for the less frequent allele — first 24 h after surgery
Valutation of the medium morphine dose (mg/kg/die) necessary to maintain NRS\<4 in the first 24 hours post-surgery in the two groups of patients, A e B. Group A: homozygous patients for the more frequent allele of the polymorphism A118G of OPRM1 gene (about 80%); group B: both homozygous and heterozygous patients for the less frequent allele (about 20%).

Countries

Italy