NCT01198912 (DOXYPOSTOP) is a Phase 2 clinical trial of doxycycline 100 mg in Chronic Rhinosinusitis, sponsored by University Hospital, Ghent.

Who is sponsoring NCT01198912?

NCT01198912 is sponsored by University Hospital, Ghent.

What drugs are being tested in NCT01198912?

Interventions in NCT01198912: placebo, doxycycline 100 mg.

What condition does NCT01198912 study?

NCT01198912 studies Chronic Rhinosinusitis, Nasal Polyps.

Is NCT01198912 still recruiting?

NCT01198912 is currently completed. Last updated 15 June 2018.

Last reviewed 2018-06-15 · How we verify

NCT01198912: DOXYPOSTOP

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Influence of Oral Doxycycline on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinusitis With and Without Nasal Polyposis: a Double-blind Randomized Placebo-controlled Trial

Completed Phase 2 Last updated 15 June 2018

What this trial tests

Phase 2 trial testing placebo in Chronic Rhinosinusitis in 33 participants. Completed in 6 February 2017.

Timeline

22 November 2011

Primary endpoint
6 September 2016

6 February 2017

Quick facts

Lead sponsor	University Hospital, Ghent
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	33
Start date	22 November 2011
Primary completion	6 September 2016
Estimated completion	6 February 2017
Sites	2 locations across Belgium, Germany

Drugs / interventions tested

placebo
doxycycline 100 mg

Conditions studied

Chronic Rhinosinusitis — all drugs for Chronic Rhinosinusitis →
Nasal Polyps — all drugs for Nasal Polyps →

Sponsor

University Hospital, Ghent

Who can join

18 and older, any sex, with Chronic Rhinosinusitis or Nasal Polyps. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a randomized, double blind, placebo controlled, parallel group, study in patients with chronic rhinosinusitis with or without nasal polyps. The objective is to test the clinical efficacy of long-term low dose oral doxycycline on wound healing quality after endoscopic sinus surgery.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Chronic Rhinosinusitis

Currently open trials in the same condition.

NCT06920576 — Effects of Esketamine Versus Magnesium Sulfate on Emotional State and Postoperative Pain in Patients Undergoing Nasal En · Phase 1, PHASE2 · active not recruiting
NCT06457100 — Esmolol Versus Lidocaine on the Quality of Postoperative Recovery in Patients Undergoing Functional Endoscopic Sinus Sur · Phase 1, PHASE2 · active not recruiting
NCT07340411 — Effect of Chinese Herbal Medicine Nasal Irrigation on the Postoperative Care of Chronic Rhinosinusitis · Phase 2 · recruiting
NCT05883462 — Paclitaxel-Coated Nasal Balloon for the Treatment of Recurrent Chronic Rhinosinusitis With or Without Nasal Polyps (FIH) · EARLY_PHASE1 · active not recruiting
NCT05935683 — Rhinosinusitis Italian Network: the Italian Registry for Severe, Uncontrolled Chronic Rhinosinusitis · recruiting

Other University Hospital, Ghent trials

Trials by the same sponsor.

NCT07584486 — Development of a New Simplified Tool to Predict LNPCPs Histology and Assess the Risk of Submucosal Invasive Cancer. The · NA · not yet recruiting
NCT07327450 — Coaching Doctors and Nurses to Improve Ethical Decision-making in Team · NA · not yet recruiting
NCT07402057 — Implementation and Evaluation of a Program Aimed at Facilitating Palliative Care Conversations · NA · recruiting
NCT07387328 — Validation of New sEMG Electrode Placement Guidelines for the Triceps Surae in Post-stroke Individuals. · not yet recruiting
NCT07237399 — Percutaneous Thermo-ablation for the Treatment of Prostate Cancer Oligometastatasis (TA-P-OLIM) · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01198912 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Ghent
Last refreshed: 15 June 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01198912.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing