Who is sponsoring NCT01193088?

NCT01193088 is sponsored by University of Iowa.

What condition does NCT01193088 study?

NCT01193088 studies Charcot-Marie-Tooth Disease, Type Ia (Disorder), HMSN.

Is NCT01193088 still recruiting?

NCT01193088 is currently recruiting now. Last updated 1 October 2025.

Last reviewed 2025-10-01 · How we verify

NCT01193088: INC-6602

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Genetics of Charcot Marie Tooth Disease (CMT) - Modifiers of CMT1A, New Causes of CMT

Recruiting now Last updated 1 October 2025

What this trial tests

trial in Charcot-Marie-Tooth Disease, Type Ia (Disorder) in 1,050 participants. Currently enrolling.

Timeline

1 May 2010

Primary endpoint
1 December 2026

1 December 2026

Quick facts

Lead sponsor	University of Iowa
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	1,050
Start date	1 May 2010
Primary completion	1 December 2026
Estimated completion	1 December 2026
Sites	22 locations across United States, Australia, Canada, Italy, United Kingdom

Conditions studied

Charcot-Marie-Tooth Disease, Type Ia (Disorder) — all drugs for Charcot-Marie-Tooth Disease, Type Ia (Disorder) →
HMSN — all drugs for HMSN →

Sponsor

University of Iowa

Who can join

Eligibility, any sex, with Charcot-Marie-Tooth Disease, Type Ia (Disorder) or HMSN. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Charcot Marie Tooth disease type 1A (CMT1A) gene modifiers
Time frame: once
While the same genetic change - an extra copy of PMP22 - causes CMT1A by definition, it is unclear why some people have more severe symptoms and some have less severe. We are looking for genetic modifiers - changes in the DNA that may be causing the differences in symptoms.
New genetic causes of CMT
Time frame: Once
At least 33% of people with CMT have an unknown or genetically un-found form of the condition. We are looking for additional genes that cause CMT when mutated.

Sponsor's own description

This project includes two projects. One is looking for new genes that cause Charcot Marie Tooth disease (CMT). The other is looking for genes that do not cause CMT, but may modify the symptoms a person has.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Whole genome sequencing increases the diagnostic rate in Charcot-Marie-Tooth disease.
Record CJ, Pipis M, Skorupinska M, Blake J, et al · · 2024 · cited 29× · PMID 38481354 · DOI 10.1093/brain/awae064
Genetic analysis and natural history of Charcot-Marie-Tooth disease CMTX1 due to GJB1 variants.
Record CJ, Skorupinska M, Laura M, Rossor AM, et al · · 2023 · cited 24× · PMID 37284795 · DOI 10.1093/brain/awad187
Disease Progression in Charcot-Marie-Tooth Disease Type 4B (CMT4B) Associated With Mutations in Myotubularin-Related Proteins 2 and 13.
Bertini A, Reilly MM, Pisciotta C, Previtali SC, et al · · 2025 · cited 1× · PMID 39943887 · DOI 10.1111/ene.70084

Verify or expand the search:

Other University of Iowa trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01193088 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Iowa
Last refreshed: 1 October 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01193088.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing