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Psychopharmacotherapy in Multiple Substances Abuse / Dependence - the Pharmacological and Immunological Approach to the New Indication of Memantine (MM opioid)
Add-on of memantine or placebo treatment will proceed in a double-blinded fashion for 12 weeks after adjusted methadone dose. During the study, the investigators will evaluate treatment response and adverse effect from multiple dimensions to elucidate the therapeutic effect of add-on memantine on addictive behaviors. It will also explore the possible advantage of this treatment on social re-adaptation and psychopathogenesis of opioid dependence.
Details
| Lead sponsor | National Cheng-Kung University Hospital |
|---|---|
| Phase | Phase 3 |
| Status | COMPLETED |
| Enrolment | 200 |
| Start date | 2009-03 |
| Completion | 2011-06 |
Conditions
- Substance Abuse
Interventions
- Memantine
Primary outcomes
- Urinary examination — baseline
Using urinary examination is aimed to test whether the patient is using substance or not. - Urinary examination — week1
Using urinary examination is aimed to test whether the patient is using substance or not. - Urinary examination — week2
Using urinary examination is aimed to test whether the patient is using substance or not. - Urinary examination — week4
Using urinary examination is aimed to test whether the patient is using substance or not. - Urinary examination — week8
Using urinary examination is aimed to test whether the patient is using substance or not. - Urinary examination — week12
Using urinary examination is aimed to test whether the patient is using substance or not.
Countries
Taiwan