19 and older, any sex, with Tobacco Smoking. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Knowledge of Genetic Contributions to SmokingPrimary· One week after completion of the two Educational Sessions (GES or NES). Educational sessions occurred over two weeks.
Knowledge of genetic contributions to smoking. Name of Scale: Genetic Knowledge Test (9 items). Minimum/Maximum Scores: 0-9. Higher score means better outcome.
Baseline
Group
Value
95% CI
Genetic Education Session (GES)
5.25
± 2.55
Nutrition Education Session (NES)
3.73
± 2.66
End of Educational Sessions
Group
Value
95% CI
Genetic Education Session (GES)
7.04
± 1.72
Nutrition Education Session (NES)
4.03
± 2.78
Smoking-Related AppraisalsPrimary· Six weeks after the baseline data collection, which was the end of the Smoking Cession Sessions.
Self-efficacy for Quitting/Resisting Smoking. Self-efficacy/Temptation Scale (Velicer, DiClemente, Rossi \& Prochaska, 1990) Total Score. Scores range from 1 to 5, with higher scores indicating greater self-efficacy. Source: Velicer, W.F., DiClemente, C.C., Rossi, J.S., \& Prochaska, J.O. (1990). Relapse situations and self-efficacy: An integrative model. Addictive Behaviors, 15, 271-283.
Baseline
Group
Value
95% CI
Genetic Education Session (GES)
3.93
± .46
Nutrition Education Session (NES)
3.99
± .70
End of Educational Sessions
Group
Value
95% CI
Genetic Education Session (GES)
3.80
± .60
Nutrition Education Session (NES)
3.86
± .69
End of Smoking Cessation Sessions
Group
Value
95% CI
Genetic Education Session (GES)
2.73
± .86
Nutrition Education Session (NES)
2.57
± 1.03
Smoking Abstinence at End of Smoking Cessation SessionsPrimary· Six weeks, which was the end of the Smoking Cessation Sessions.
Number of participants reporting Smoking Abstinence at the end of the Smoking Cessation Sessions and who had a carbon monoxide (CO) measurement of 6 ppm or less.
Group
Value
95% CI
Genetic Education Session (GES)
11
Nutrition Education Session (NES)
10
Genetic Education Session (GES)
17
Nutrition Education Session (NES)
15
Sponsor's own description
This study will test the effects of an educational program about genetics and smoking on smokers' thoughts, feelings, and behaviors before and after participating in smoking cessation treatment. This includes describing participants' knowledge about genetics and smoking, their use of strategies to stop smoking, and experiences when quitting smoking. This study will determine how smokers respond to information about genetics and smoking in anticipation of using genetic information to individualize pharmacological therapy for smoking cessation.
Two groups will participate in this study. The experimental group will participate in two educational sessions about genetics and smoking. The control group will participate in two educational sessions about nutrition. Both the experimental and control groups will participate in a standard, group smoking cessation program with 6 weeks of over-the-counter (OTC) transdermal nicotine replacement therapy. Assignment to either of the two groups is random.
The primary specific aim is to compare the effects of the experimental group to the attention control group on smoking-related mental representations, appraisals, behaviors, and affective responses over time. The secondary aim is to explore whether personality characteristics (trait negative affectivity and curiosity) and educational level moderate the effects of the genetic educational program on smoking-related mental representations, appraisals, behaviors, and affective responses. The hypotheses of the study are as follows:
1. When compared to the attention control group, the experimental group will demonstrate:
* Smoking-Related Mental Representations:
* Greater knowledge of genetic contributions to smoking
* Greater endorsement of genetic contributions to smoking
* More positive attitudes towards NRT
* Increased abstainer and decreased smoker self-schemas
* Smoking-Related Appraisal: greater perceived risk for genetic predispositions to smoking
* Smoking-Related Behaviors: greater interest in genotyping.
2. When compared to the attention control group, the experimental group will differ in:
* Smoking-Related Appraisals: self-efficacy for cessation and abstinence
* Smoking-Related Behaviors: number of quit attempts, abstinence, nicotine dependence
* Affective Responses: negative affect and intrusive/avoidant thoughts
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Nebraska
Last refreshed: 4 October 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01186016.