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Does Inhaled Fluticasone REsult in Obstructive Sleep Apnea? DREAM-A Pilot Study
This study is being conducted to find out if the use of inhaled corticosteroids has an affect on upper airway (UAW) collapsibility and sleep apnea risk. An inhaled corticosteroid is a common asthma controller medication like Flovent. Sleep apnea or sleep deprived breathing (SDB) is when someone stops breathing for a short period of time during sleep. For some reason, people with asthma have more sleep apnea and upper airway (UAW) collapsibility (weakness) than the general population. There are many possible reasons for this and one might be related to the use of inhaled corticosteroids. The overall hypothesis of this study is to determine whether inhaled fluticasone propionate (FP) increases UAW collapsibility and to assess tongue (genioglossus muscle) dysfunction as a potential underlying mechanism.
Details
| Lead sponsor | University of Wisconsin, Madison |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 36 |
| Start date | 2009-03 |
| Completion | 2011-02 |
Conditions
- Lung Disease
Interventions
- FP 220 mcg 2 puffs BID
Primary outcomes
- Number of Participants With Improved, Unchanged, and Worsened Critical Closing Pressure (Pcrit) From Baseline With 16-week of High Dose Inhaled FP Treatment. — 16 weeks
Upper airway (UAW) collapsibility, as measured by critical closing pressure (Pcrit), defined as the maximum nasal pressure at which the UAW occludes. Subjects were divided into 3 subgroups: improved (more negative Pcrit), unchanged, or worsened (less negative Pcrit).
Countries
United States