NCT01180712

Study of Oral Anthocyanins on Insulin Resistance

Completed NA Last updated 1 August 2019

What this trial tests

NA trial testing Mirtoselect in Type 2 Diabetes in 16 participants. Completed in 1 May 2019.

Timeline

1 June 2010

Primary endpoint
1 May 2019

1 May 2019

Quick facts

Lead sponsor	University of Aberdeen
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	quadruple
Primary purpose	treatment
Enrollment	16
Start date	1 June 2010
Primary completion	1 May 2019
Estimated completion	1 May 2019
Sites	1 location across United Kingdom

Drugs / interventions tested

• Mirtoselect

Conditions studied

• Type 2 Diabetes — all drugs for Type 2 Diabetes →

Sponsor

University of Aberdeen

Who can join

Adults 40 to 70, male only, with Type 2 Diabetes. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

• Oral Glucose Tolerance Test
  Time frame: Day 0 and 21 days post intervention
  Change in Oral Glucose Tolerance following intervention

Sponsor's own description

Dietary strategies for alleviating the metabolic complications such as diabetes associated with obesity are actively being pursued as alternatives to pharmaceutical interventions The genus Vaccinium (e.g. blueberry, blaeberry, cranberry) has been used traditionally as a source of folk remedies for established diabetic symptoms, primarily as leaf or stem infusions or decoctions. Berries from this family such as blaeberry (BL) and blueberry (BB) are enriched in anthocyanins, polyphenolics recognized for their ability to provide and activate cellular antioxidant protection, inhibit inflammatory gene expression, and consequently protect against oxidant-induced and inflammatory cell damage and cytotoxicity. The association of obesity with adipose tissue stress, macrophage recruitment, and inflammatory gene expression suggests that eating edible berries from this genus might provide an effective alternative or supplementary intervention to attenuate obesity- associated inflammation and the associated insulin resistance.

The aim of this study is to determine the effects of anthocyanin supplementation in the form of a concentrated blaeberry extract on insulin resistance and inflammation particularly in the adipose tissue following a three week supplementation period.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

1. Dietary Anthocyanins and Insulin Resistance: When Food Becomes a Medicine.
   Belwal T, Nabavi SF, Nabavi SM, Habtemariam S. · · 2017 · cited 94× · PMID 29023424 · DOI 10.3390/nu9101111
2. Antiobesity Effects of Anthocyanins in Preclinical and Clinical Studies.
   Azzini E, Giacometti J, Russo GL. · · 2017 · cited 62× · PMID 28785373 · DOI 10.1155/2017/2740364
3. Anthocyanins in the Management of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review.
   Naseri R, Farzaei F, Haratipour P, Nabavi SF, et al · · 2018 · cited 51× · PMID 30564116 · DOI 10.3389/fphar.2018.01310
4. The Role of Dietary Anthocyanins for Managing Diabetes Mellitus-Associated Complications.
   Mistry PS, Chorawala MR, Sivamaruthi BS, Prajapati BG, et al · · 2025 · cited 6× · PMID 39136514 · DOI 10.2174/0115733998322754240802063730
5. Evidence-Based Anti-Diabetic Properties of Plant from the Occitan Valleys of the Piedmont Alps.
   Boscaro V, Rivoira M, Sgorbini B, Bordano V, et al · · 2022 · cited 4× · PMID 36365189 · DOI 10.3390/pharmaceutics14112371