NCT01173848 (UPGRADE) is a Phase 3 clinical trial of Ergocalciferol in Chronic Kidney Disease Stage 3 and 4, sponsored by The Cleveland Clinic.

Who is sponsoring NCT01173848?

NCT01173848 is sponsored by The Cleveland Clinic.

What drugs are being tested in NCT01173848?

Interventions in NCT01173848: Ergocalciferol, Cholecalciferol.

What condition does NCT01173848 study?

NCT01173848 studies Chronic Kidney Disease Stage 3 and 4.

Is NCT01173848 still recruiting?

NCT01173848 is currently terminated. Last updated 30 March 2017.

Are results published for NCT01173848?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2017-03-30 · How we verify

NCT01173848: UPGRADE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A Randomized Study to Evaluate the Effectiveness of Cholecalciferol Versus Ergocalciferol Following Kidney Disease Outcomes Quality Initiative (K/DOQI) Guidelines for Vitamin D Therapy in Stages 3 & 4 Chronic Kidney Disease (CKD) Patients

Terminated Phase 3 Results posted Last updated 30 March 2017

What this trial tests

Phase 3 trial testing Ergocalciferol in Chronic Kidney Disease Stage 3 and 4 in 19 participants. Terminated before completion.

Timeline

1 July 2010

Primary endpoint
1 September 2011

18 October 2011

Quick facts

Lead sponsor	The Cleveland Clinic
Phase	Phase 3
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	19
Start date	1 July 2010
Primary completion	1 September 2011
Estimated completion	18 October 2011
Sites	1 location across United States

Drugs / interventions tested

Ergocalciferol (ERGOCALCIFEROL) — full drug profile →
Cholecalciferol (cholecalciferol) — full drug profile →

Conditions studied

Chronic Kidney Disease Stage 3 and 4 — all drugs for Chronic Kidney Disease Stage 3 and 4 →

Sponsor

The Cleveland Clinic

Who can join

Adults 18 to 99, any sex, with Chronic Kidney Disease Stage 3 and 4. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Subjects Achieving Normal Vitamin D Levels
Time frame: within 24 weeks

Sponsor's own description

The purpose of this study is to examine the effectiveness of vitamin D3 versus vitamin D2 in raising vitamin D levels and suppressing parathyroid hormone levels in patients with kidney disease who are not on dialysis.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Which vitamin D in CKD-MBD? The time of burning questions.
Galassi A, Bellasi A, Auricchio S, Papagni S, et al · · 2013 · cited 15× · PMID 23991423 · DOI 10.1155/2013/864012

Verify or expand the search:

Other trials of Ergocalciferol

Trials testing the same drug.

NCT05619289 — Immune Mechanisms of Vitamin D to Reduce Chronic Pain After Burn · Phase 2 · completed
NCT03747523 — Pilot Study: The Effect of Ergocalciferol on Plasma Mucin-1 Levels · EARLY_PHASE1 · completed
NCT03046927 — Vitamin D and Residual Beta-Cell Function in Type 1 Diabetes · Phase 2, PHASE3 · completed
NCT03228862 — Optimal Doses of Ergocalciferol Supplementation for Treatment of Hypovitaminosis D in Adults · Phase 4 · unknown

Other recruiting trials for Chronic Kidney Disease Stage 3 and 4

Currently open trials in the same condition.

NCT06933108 — Prediction of Peripheral Neuropathy With Functional Testing · recruiting
NCT06621264 — Exercise Activity to Improve Mobility in Patients With CKD and PAD · NA · recruiting

Other The Cleveland Clinic trials

Trials by the same sponsor.

NCT07218198 — Clinical Decision Support Tool for the Treatment of Uncontrolled Hypertension · NA · not yet recruiting
NCT07442747 — Neural Mechanisms of Aerobic Exercise Benefits in PD With DBS · NA · not yet recruiting
NCT07471464 — Centered Surgery - Preoperative Counseling and Patient Satisfaction · recruiting
NCT07073963 — Virtual Patient Groups for Sarcoidosis Associated Fatigue · NA · recruiting
NCT07363343 — Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01173848 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The Cleveland Clinic
Last refreshed: 30 March 2017

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01173848.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing