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Effect of Vitamin D Oral Supplements on 25 OH Vitamin D Levels: A Randomized Controlled Trial
Vitamin D deficiency is common world wide. 25 OH vitamin D level is the best indicator of vitamin D status. Vitamin D supplements are available as vitamin D2 or D3, in small daily or large weekly/monthly doses. Controversy continues on the relative potency of vitamin D2 compared to D3 and of daily compared to weekly or monthly doses, in increasing/maintaining total 25 OH vitamin D level. The investigators plan to conduct a controlled trial to compare the effect of various vitamin D supplements on 25 OH vitamin D levels in healthy adults with starting 25 OH vitamin D level between 20 to 50 nmol/L.
Details
| Lead sponsor | King Faisal Specialist Hospital & Research Center |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 279 |
| Start date | 2013-02 |
| Completion | 2016-04 |
Conditions
- Vitamin D Deficiency
Interventions
- ergocalciferol 2000 IU orally, daily
- ergocalciferol 25000 IU oraly every 2 weeks
- ergocalciferol 50000 IU orally every 4 weeks
- ergocal1000 IU & cholecal 1000 IU orally daily
- cholecalciferol 2000 IU orally daily
- Cholecalciferol 25000 IU orally every 2 weeks
- Cholecalciferol 50000 orally every 4 weeks
- placebo orally everyday
Primary outcomes
- area under the curve of 25 OH vitamin D level — 140 days
area under the curve of total 25 OH vitamin D level from day 1 to 140
Countries
Saudi Arabia