PROTOCOL FOR PHASE II CLINICAL TRIAL, RANDOMIZED AND OPEN FOR ETIOLOGICAL TREATMENT OF CHRONIC CHAGAS DISEASE WITH POSACONAZOLE AND BENZNIDAZOLE (CHAGASAZOL)

NCT01162967 Phase 2 COMPLETED

The investigators propose the evaluation of posaconazole and benznidazole in humans for the treatment of Chagas disease chronical infection. Exploratory trial of posaconazole antiparasitic activity against Trypanosoma cruzi.

Details

Lead sponsor	Hospital Universitari Vall d'Hebron Research Institute
Phase	Phase 2
Status	COMPLETED
Enrolment	78
Start date	2010-09
Completion	2013-03

Conditions

• Chagas Disease

Interventions

• Benznidazole
• Posaconazole

Primary outcomes

• Parasitological cure measured by a real time PCR in blood sample — 12 months after starting treatment
  PCR negative at the end of follow up

Countries

Spain