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Corneal Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic Riboflavin
Corneal collagen crosslinking (CXL) has been proposed as an effective method of reducing progression of both keratoconus and corneal ectasia after surgery, as well as possibly decreasing the steepness of the cornea in these pathologies. During the CXL procedure, the central corneal thickness has been shown to significantly change. The investigator's believe that better maintenance of corneal thickness potentially could have benefits of better reproducibility of the crosslinking effect with improved predictability of results.
Details
| Lead sponsor | Cornea and Laser Eye Institute |
|---|---|
| Phase | Phase 3 |
| Status | UNKNOWN |
| Enrolment | 160 |
| Start date | 2010-06 |
| Completion | 2025-12 |
Conditions
- Keratoconus
- Corneal Ectasia
Interventions
- Riboflavin/Dextran
- Hypotonic Riboflavin
Primary outcomes
- Corneal thickness — Intraoperatively
Changes in central pachymetry (as measured by ultrasound) measured intraoperatively will be compared to a baseline preoperative value. Thickness will also be assessed at 1, 3, 6 and 12 months postoperatively.
Countries
United States