Last reviewed · How we verify
NCT01148550: MITOHEP
Longitudinal Study of Mitochondrial Hepatopathies
trial in Acute Liver Failure in 90 participants. Suspended.
31 May 2029
Quick facts
| Lead sponsor | Arbor Research Collaborative for Health |
|---|---|
| Status | Suspended |
| Study type | OBSERVATIONAL |
| Enrollment | 90 |
| Start date | 18 August 2010 |
| Primary completion | 31 May 2029 |
| Estimated completion | 31 May 2029 |
| Sites | 16 locations across Canada, United States |
Conditions studied
- Acute Liver Failure — all drugs for Acute Liver Failure →
- Mitochondrial Diseases — all drugs for Mitochondrial Diseases →
- End Stage Liver Disease — all drugs for End Stage Liver Disease →
- Respiratory Chain Deficiencies, Mitochondrial — all drugs for Respiratory Chain Deficiencies, Mitochondrial →
Sponsor
Arbor Research Collaborative for Health
Who can join
Under 18, any sex, with Acute Liver Failure or Mitochondrial Diseases. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The specific aims of this study are (1) to determine the clinical phenotypes and natural history of hepatic RC and FAO disorders, (2) to determine the correlation between genotype and phenotype, (3) to determine if circulating biomarkers reflect diagnosis and predict liver disease progression and survival with the native liver, (4) to determine the clinical outcome of these disorders following liver transplantation, and (5) to develop a repository of serum, plasma, urine, tissue and DNA specimens that will be used in ancillary studies. To accomplish these aims, the ChiLDReN investigators at clinical sites (currently 9 sites) will prospectively collect defined data and specimens in a uniform fashion at fixed intervals in a relatively large number of subjects. Clinical information collected from subjects and their parents will enhance the potential for meaningful research in these disorders. A biobank of previously collected subject specimens and DNA samples will be established for use in ancillary studies to be performed in addition to this study.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Clinical spectrum and genetic causes of mitochondrial hepatopathy phenotype in children.
Squires JE, Miethke AG, Valencia CA, Hawthorne K, et al · · 2023 · cited 9× · PMID 37184518 · DOI 10.1097/hc9.0000000000000139 -
Protein biomarkers GDF15 and FGF21 to differentiate mitochondrial hepatopathies from other pediatric liver diseases.
Van Hove JLK, Friederich MW, Strode DK, Van Hove RA, et al · · 2024 · cited 8× · PMID 38180987 · DOI 10.1097/hc9.0000000000000361
Verify or expand the search:
- PubMed search for NCT01148550
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Acute Liver Failure
Currently open trials in the same condition.
- NCT06831643 — Standard Volume vs. High Volume Plasma Exchange in Pediatric Acute Liver Failure · NA · recruiting
- NCT06872372 — Role of N-Acetylcysteine in Non-Acetaminophen-Induced Acute Liver Failure · NA · active not recruiting
- NCT07329036 — ALSS - DPMAS and Therapeutic Plasma Exchange (TPE), Its Effect on Primary Coagulation, Inflammation and the Function of · NA · recruiting
- NCT05689645 — F573 for Injection for the Treatment of Liver Injury/Failure · Phase 2 · recruiting
- NCT05413083 — Evaluation of Cardiac Function in Acutely Decompensated Cirrhosis · active not recruiting
Other Arbor Research Collaborative for Health trials
Trials by the same sponsor.
- NCT05272319 — Genetic Collection Protocol · recruiting
- NCT04181138 — Primary Sclerosing Cholangitis in Children · recruiting
- NCT04970056 — Pancreatic Cancer Early Detection Consortium · recruiting
- NCT03350269 — Effect of Lost Wage Reimbursement to Kidney Donors on Living Donation Rates · NA · terminated
- NCT03808038 — Symptoms of Lower Urinary Tract Dysfunction Protocol 2/Recall Study · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT01148550 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Arbor Research Collaborative for Health
- Last refreshed: 15 October 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01148550.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing