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NCT01142427
Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
Completed
Last updated 3 October 2023
What this trial tests
trial testing Cytology Specimen Collection Procedure in Acute Lymphoblastic Leukemia in 17,463 participants. Completed in 30 September 2023.
Timeline
9 August 2010
Primary endpoint
1 May 2015
1 May 2015
30 September 2023
Quick facts
| Lead sponsor | Children's Oncology Group |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 17,463 |
| Start date | 9 August 2010 |
| Primary completion | 1 May 2015 |
| Estimated completion | 30 September 2023 |
| Sites | 244 locations across New Zealand, Ireland, Canada, Puerto Rico, Australia, Switzerland, United States |
Drugs / interventions tested
- Cytology Specimen Collection Procedure
- Laboratory Biomarker Analysis — full drug profile →
Conditions studied
- Acute Lymphoblastic Leukemia — all drugs for Acute Lymphoblastic Leukemia →
Sponsor
Children's Oncology Group — full company profile →
Who can join
Under 30, any sex, with Acute Lymphoblastic Leukemia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This research trial studies a risk-based classification system for patients with newly diagnosed acute lymphoblastic leukemia. Gathering health information about patients with acute lymphoblastic leukemia may help doctors learn more about the disease and plan the best treatment.
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
-
Impact of Asparaginase Discontinuation on Outcome in Childhood Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group.
Gupta S, Wang C, Raetz EA, Schore R, et al · · 2020 · cited 136× · PMID 32275469 · DOI 10.1200/jco.19.03024 -
The genomic basis of childhood T-lineage acute lymphoblastic leukaemia.
Pölönen P, Di Giacomo D, Seffernick AE, Elsayed A, et al · · 2024 · cited 96× · PMID 39143224 · DOI 10.1038/s41586-024-07807-0 -
Excellent Outcomes With Reduced Frequency of Vincristine and Dexamethasone Pulses in Standard-Risk B-Lymphoblastic Leukemia: Results From Children's Oncology Group AALL0932.
Angiolillo AL, Schore RJ, Kairalla JA, Devidas M, et al · · 2021 · cited 76× · PMID 33411585 · DOI 10.1200/jco.20.00494 -
Mixed-phenotype acute leukemia: A cohort and consensus research strategy from the Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force.
Orgel E, Alexander TB, Wood BL, Kahwash SB, et al · · 2020 · cited 46× · PMID 31661160 · DOI 10.1002/cncr.32552 -
Flow-cytometric vs. -morphologic assessment of remission in childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group (COG).
Gupta S, Devidas M, Loh ML, Raetz EA, et al · · 2018 · cited 36× · PMID 29472723 · DOI 10.1038/s41375-018-0039-7 -
Genomic landscape of Down syndrome-associated acute lymphoblastic leukemia.
Li Z, Chang TC, Junco JJ, Devidas M, et al · · 2023 · cited 35× · PMID 37001051 · DOI 10.1182/blood.2023019765 -
Trial Design Challenges and Approaches for Precision Oncology in Rare Tumors: Experiences of the Children's Oncology Group.
Renfro LA, Ji L, Piao J, Onar-Thomas A, et al · · 2019 · cited 17× · PMID 32923863 · DOI 10.1200/po.19.00060 -
Minimal Residual Disease Evaluation in Childhood Acute Lymphoblastic Leukemia: An Economic Analysis.
Health Quality Ontario. · · 2016 · cited 6× · PMID 27099644
Verify or expand the search:
- PubMed search for NCT01142427
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Currently open trials in the same condition.
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Other Children's Oncology Group trials
Trials by the same sponsor.
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- NCT07022678 — Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia · Phase 3 · not yet recruiting
- NCT07072585 — Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leuk · Phase 2, PHASE3 · not yet recruiting
- NCT06858501 — Comparing 123I-MIBG and 18F-MFBG Imaging in Patients With Newly Diagnosed, High Risk Neuroblastoma · Phase 2 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
Data sources for this page
- Trial protocol + status: ClinicalTrials.gov NCT01142427 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Children's Oncology Group
- Last refreshed: 3 October 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01142427.
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