NCT01132859

VRC 900: Evaluation of Tissue-Specific Immune Responses in Adults 18 Years of Age and Older

Recruiting now Last updated 14 April 2026

What this trial tests

trial in Immunity, Mucosal in 500 participants. Currently enrolling.

Timeline

18 May 2010

Quick facts

Lead sponsor	National Institute of Allergy and Infectious Diseases (NIAID)
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	500
Start date	18 May 2010
Sites	1 location across United States

Conditions studied

• Immunity, Mucosal — all drugs for Immunity, Mucosal →
• Immune System Processes — all drugs for Immune System Processes →
• Blood Specimen Collection — all drugs for Blood Specimen Collection →

Sponsor

National Institute of Allergy and Infectious Diseases (NIAID)

Who can join

Adults 18 to 120, any sex, with Immunity, Mucosal or Immune System Processes. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background:

\- The Vaccine Research Center (VRC) is dedicated to understanding immune responses associated with prevention and treatment of infectious diseases. To study these immune responses, researchers need to collect specimens and images from individuals who have recently had a vaccination or recovered from an infection. These specimens and images are used to study different diseases and immune responses, and can be used to investigate ways to prevent or treat different medical conditions.

Objectives:

\- To evaluate blood and other tissue samples for immune responses to vaccines and natural infections.

Eligibility:

\- Healthy volunteers at least 18 years of age who agree to donate specimens for research purposes.

Design:

* Participants will have clinical evaluations and will be asked to provide some of the following samples, depending on the research question being addressed. All procedures and sample donations are optional and voluntary:
* Blood samples through regular blood draws (for whole blood) and apheresis (to collect specific parts of the blood such as plasma or white blood cells)
* Urine, semen, saliva, or vaginal swab samples
* Tissue samples or biopsy specimens
* Undergo procedures such as bronchoscopy (lung and respiratory tract), gastrointestinal endoscopy (stomach and upper intestinal tract), or colonoscopy (lower intestinal tract) to obtain tissue samples
* Undergo imaging studies such as positron emission tomography (PET) or computed tomography (CT) scans

Duration of participation is variable depending on the research question but will usually last up to 1 year.

\- Participants will be compensated for participation.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

1. Comparison of adaptive and innate immune responses induced by licensed vaccines for Human Papillomavirus.
   Herrin DM, Coates EE, Costner PJ, Kemp TJ, et al · · 2014 · cited 60× · PMID 25483691 · DOI 10.4161/hv.34408
2. Lymph Node Activation by PET/CT Following Vaccination With Licensed Vaccines for Human Papillomaviruses.
   Coates EE, Costner PJ, Nason MC, Herrin DM, et al · · 2017 · cited 57× · PMID 28288041 · DOI 10.1097/rlu.0000000000001603
3. Circulating CXCR5⁺CD4⁺ T Follicular-Like Helper Cell and Memory B Cell Responses to Human Papillomavirus Vaccines.
   Matsui K, Adelsberger JW, Kemp TJ, Baseler MW, et al · · 2015 · cited 39× · PMID 26333070 · DOI 10.1371/journal.pone.0137195
4. Differences in HPV-specific antibody Fc-effector functions following Gardasil® and Cervarix® vaccination.
   Roy V, Jung W, Linde C, Coates E, et al · · 2023 · cited 18× · PMID 36922512 · DOI 10.1038/s41541-023-00628-8
5. Hemagglutinin-displaying influenza nanovaccines: progress and promise.
   Kim D, Duffy A, Wee A, Hammond H, et al · · 2026 · PMID 41355431 · DOI 10.1080/17435889.2025.2598329