NCT01109394

Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related Biological Studies

Recruiting now Last updated 14 April 2026

What this trial tests

trial in Sarcoma in 6,035 participants. Currently enrolling.

Timeline

21 April 2010

Quick facts

Lead sponsor	National Cancer Institute (NCI)
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	6,035
Start date	21 April 2010
Sites	5 locations across United States

Conditions studied

• Sarcoma — all drugs for Sarcoma →
• Endocrine Tumors — all drugs for Endocrine Tumors →
• Neuroblastoma — all drugs for Neuroblastoma →
• Retinoblastoma — all drugs for Retinoblastoma →

Sponsor

National Cancer Institute (NCI)

Who can join

4 Weeks and older, any sex, with Sarcoma or Endocrine Tumors. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background:

\- Laboratory investigators who are studying common childhood cancers are interested in developing a tissue repository to collect and store blood, serum, tissue, urine, or tumors of children who have cancer or adults who have common childhood cancers. To develop this repository, additional samples will be collected from children and adults who have been diagnosed with common childhood cancers such as leukemia and tumors of the central nervous system.

Objectives:

\- To collect and store blood, serum, tissue, urine, or tumor samples of children who have cancer or adults who have common childhood cancers.

Eligibility:

* Individuals who have been diagnosed with a common childhood cancer (e.g., leukemia) regardless of patient age.
* Children, adolescents, and adults who have been diagnosed with a type of cancer more commonly found in adults.

Design:

* Extra blood, serum (the liquid part of blood), tissue, urine, or tumor samples will be collected from participants at a time when sampling is required for medical care or as part of a research study.
* No additional procedures will be performed for the sole purpose of obtaining additional tumor tissue, aside from what is required for clinical care.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. MultiDimensional ClinOmics for Precision Therapy of Children and Adolescent Young Adults with Relapsed and Refractory Cancer: A Report from the Center for Cancer Research.
   Chang W, Brohl AS, Patidar R, Sindiri S, et al · · 2016 · cited 97× · PMID 26994145 · DOI 10.1158/1078-0432.ccr-15-2717
2. Cell-free DNA ultra-low-pass whole genome sequencing to distinguish malignant peripheral nerve sheath tumor (MPNST) from its benign precursor lesion: A cross-sectional study.
   Szymanski JJ, Sundby RT, Jones PA, Srihari D, et al · · 2021 · cited 62× · PMID 34464388 · DOI 10.1371/journal.pmed.1003734
3. Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors.
   Akhavanfard S, Padmanabhan R, Yehia L, Cheng F, et al · · 2020 · cited 54× · PMID 32371905 · DOI 10.1038/s41467-020-16067-1
4. Tumor Mutation Burden, Expressed Neoantigens and the Immune Microenvironment in Diffuse Gliomas.
   Yu G, Pang Y, Merchant M, Kesserwan C, et al · · 2021 · cited 29× · PMID 34885201 · DOI 10.3390/cancers13236092
5. Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor.
   Zhang X, Lou HE, Gopalan V, Liu Z, et al · · 2022 · cited 23× · PMID 36130486 · DOI 10.1016/j.celrep.2022.111363
6. Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma.
   Akshintala S, Sundby RT, Bernstein D, Glod JW, et al · · 2023 · cited 16× · PMID 37398992 · DOI 10.1158/1078-0432.ccr-23-0709
7. Preclinical and Clinical Applications of Metabolomics and Proteomics in Glioblastoma Research.
   Ahmed M, Semreen AM, El-Huneidi W, Bustanji Y, et al · · 2022 · cited 16× · PMID 36613792 · DOI 10.3390/ijms24010348
8. Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics.
   Sundby RT, Szymanski JJ, Pan AC, Jones PA, et al · · 2024 · cited 14× · PMID 39093127 · DOI 10.1158/1078-0432.ccr-24-0797