Pre-Operative Inhibition of the Angiotensin System Study: A Prospective Randomized Single-Blinded Trial of Pre-Operative Management of Medications That Inhibit the Renin-Angiotensin System (PASS)

NCT01091961 NA COMPLETED

Patients on a stable dose of ACE inhibitor or ARB medication who are scheduled for elective surgery will be randomized to take their ACE inhibitor or ARB up to and including the morning of surgery, or to hold them a day prior to the surgery. The patients will be followed for 30 days after surgery to assess any adverse health outcomes.

Details

Lead sponsor	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Phase	NA
Status	COMPLETED
Enrolment	200
Start date	2010-01
Completion	2011-12

Conditions

• Hypertension

Interventions

• Preoperative ACEi/ARB management

Primary outcomes

• Mean arterial blood pressure — 24 hours after surgery

Countries

Canada