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Investigate the Relationship Between CYP2C19 Genetic Polymorphisms and Pharmacokinetics of Glipizide in Healthy Chinese Subjects
Diabetes mellitus is a growing global disease now and future, and in China, 1.2 million peoples per year have been diagnosed as diabetes mellitus. 90% diabetes mellitus patient is Type 2 diabetes mellitus. Glipizide is a potent drug to service patients who suffer from Type 2 disease. Little information has been presented for the relationship between CYP2C19 genetic polymorphism and glipizide, since recently the investigators reported that there existed a tendency. In this study the investigators found that CYP2C19 polymorphism significantly influenced the pharmacokinetics of glipizide.
Details
| Lead sponsor | Chinese Academy of Sciences |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 14 |
| Start date | 2009-11 |
| Completion | 2010-01 |
Conditions
- Genotype
- Pharmacokinetic
Interventions
- Glipizide
Countries
China