Phase 1 and Phase 2a Clinical Trial:Immunization of Human Volunteers With P. Vivax Irradiated Sporozoites (SPZ-Irrad)

NCT01082341 Phase 1/Phase 2 COMPLETED

It is possible to safely protect human volunteers immunized with P. vivax irradiated sporozoites from P. vivax challenge with live sporozoites.

Details

Lead sponsor	Malaria Vaccine and Drug Development Center
Phase	Phase 1/Phase 2
Status	COMPLETED
Enrolment	27
Start date	2012-06
Completion	2017-09

Conditions

• Malaria

Interventions

• Immunization with P. vivax irradiated sporozoites

Primary outcomes

• Three groups are considered to be intervened. Experimental, Control and Fy(-) groups. Comparison will be done between E and C groups for protective efficacy. For immune response tests E vs Fy(-),E vs Fy(-), and Fy(-) vs C, pairs will be compared. — 2 years

Countries

Colombia