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NCT01070212
Effects of Gum Chewing on Appetite and Digestion
NA trial testing soft gum in The Null Hypothesis is That Food Rheology Will Have no Effect on These Indices in 60 participants. Completed in 1 January 2012.
1 January 2012
Quick facts
| Lead sponsor | Purdue University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 60 |
| Start date | 1 February 2010 |
| Primary completion | 1 January 2012 |
| Estimated completion | 1 January 2012 |
| Sites | 2 locations across United States |
Drugs / interventions tested
- soft gum
- firm gum
- no gum
Conditions studied
- The Null Hypothesis is That Food Rheology Will Have no Effect on These Indices — all drugs for The Null Hypothesis is That Food Rheology Will Have no Effect on These Indices →
- The Alternate Hypothesis is That Increased Mechanical Stimulation Will Result in Stronger Satiation/Satiety and Reduced Energy Intake — all drugs for The Alternate Hypothesis is That Increased Mechanical Stimulation Will Result in Stronger Satiation/Satiety and Reduced Energy Intake →
- It is Hypothesized That the Effects of Mastication Will be Less Evident in Obese Compared to Lean Individuals — all drugs for It is Hypothesized That the Effects of Mastication Will be Less Evident in Obese Compared to Lean Individuals →
Sponsor
Purdue University
Who can join
Adults 18 to 50, any sex, with The Null Hypothesis is That Food Rheology Will Have no Effect on These Indices or The Alternate Hypothesis is That Increased Mechanical Stimulation Will Result in Stronger Satiation/Satiety and Reduced Energy Intake. Healthy volunteers can join.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Effects of mastication on appetite.
Time frame: 12 hours
Effects of varying chewing intensity on self-rated hunger, fullness, desire to eat and thirst.
Sponsor's own description
One obvious property difference between energy-yielding beverages and solid foods is the oral mechanical processing required to prepare the two food forms for swallowing. Considerable human data are consistent with a contribution of mechanical stimulation to appetite suppression. However, no study has isolated this property and assessed its influence on ingestive behavior in humans. This is the aim of the present study. The null hypothesis is that food rheology will have no effect on these indices. The alternate hypothesis is that increased mechanical stimulation will result in stronger satiation/satiety and reduced energy intake. Further, it is hypothesized that the effects of mastication will be less evident in obese compared to lean individuals.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT01070212
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT01070212 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Purdue University
- Last refreshed: 11 December 2023
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