Reload of High Dose Atorvastatin for Preventing Deep Vein Thrombosis in Statin Users Undergoing Total Knee Replacement Arthroplasty: RE-STOP-DVT Study- A Prospective Randomized Controlled Trial (Re-STOP DVT)

NCT01063426 Phase 4 UNKNOWN

Reload of high dose statin may have potential for preventing deep vein thrombosis (DVT) in patients on statin undergoing total knee replacement arthroplasty. A body of evidence have been reported that reloading of atorvastatin have efficacy in reducing periprocedural myocardial infarction and contrast induced nephropathy. These effects are considered to be mainly due to their antioxidant anti-thrombotic and anti-inflammatory property. We, therefore, hypothesize that high dose atorvastatin re-loading may prevent DVT.

Details

Lead sponsor	Hallym University Medical Center
Phase	Phase 4
Status	UNKNOWN
Enrolment	180
Start date	2009-11
Completion	2012-03

Conditions

• Thrombosis
• Prevention
• Surgery

Interventions

• High dose Atorvastatin+enoxaparin
• Enoxaparin

Primary outcomes

• Development of deep vein thrombosis diagnosed and confirmed by CT angiography at lower extremities — 7days after index surgery

Countries

South Korea