Comparison of High-dose Furosemide, Low-dose Furosemide, and the Combination of Low-dose Furosemide and Low-dose Dopamine in Patients With Acute Decompensated Heart Failure (DAD-HF II)

NCT01060293 Phase 4 TERMINATED

The aim of this study is to compare the effects of 1) high-dose furosemide, 2) low-dose furosemide, and 3) low-dose furosemide combined with low-dose dopamine on diuresis, clinical status, renal function, electrolyte balance, length of stay, and 60-day post-discharge outcomes in patients hospitalized with acute decompensated heart failure.

Details

Lead sponsor	Larissa University Hospital
Phase	Phase 4
Status	TERMINATED
Enrolment	161
Start date	2009-07
Completion	2013-12

Conditions

• Acute Decompensated Heart Failure

Interventions

• High-dose furosemide
• Low-dose furosemide
• Low-dose furosemide combined with low-dose dopamine

Primary outcomes

• 1-year mortality or rehospitalization (all-cause, cardiovascular, non-cardiovascular, and due to worsening heart failure). — 1-year

Countries

United States, Greece