Effect of Nebivolol on Blood Pressure in a Model of Hypertension Sensitive to Potentiation of Nitric Oxide Bioactivity

NCT01044693 NA COMPLETED Results posted

The purpose of this study is to evaluate the effect of the antihypertensive drug, nebivolol (Bystolic), compared to metoprolol (Lopressor) and sildenafil (Viagra) on blood pressure in patients with autonomic failure and supine hypertension.

Details

Lead sponsor	Vanderbilt University
Phase	NA
Status	COMPLETED
Enrolment	20
Start date	2010-01
Completion	2014-08

Conditions

• Hypertension
• Pure Autonomic Failure
• Multiple System Atrophy

Interventions

• Placebo
• Nebivolol 5 mg
• metoprolol tartrate 50 mg
• Sildenafil25 mg

Primary outcomes

• Change in Systolic Blood Pressure During the Night — 8 pm - 8 am
  Maximal change from baseline in systolic blood pressure, measured from 8 pm to 8 am, after a single dose of the intervention

Countries

United States