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Medication Effects on Periurethral Sensation, Urethral Sphincter Activity and Pressure Flow Parameters
Lower urinary tract symptoms such as urinary leakage and overactive bladder affect millions of American women. Women may develop these problems because the innervation of the muscles of the bladder and urethra are injured. Most research on treating these problems has focused on the abnormalities of the bladder muscle, but newer studies have shown abnormalities in the innervation and muscle function of the urethra. Women with these symptoms may benefit from treatment with medications to improve their urethral function. However, to truly understand what types of medications will help women with these symptoms, the investigators wish to study how these medications affect innervation and muscle function in healthy women who do not have lower urinary tract symptoms.
Details
| Lead sponsor | University of Alabama at Birmingham |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 56 |
| Start date | 2010-04 |
| Completion | 2011-04 |
Conditions
- Urethral Sphincter Activity
Interventions
- Pseudoephedrine
- Tamsulosin
- Imipramine
- Cyclobenzaprine
- Lactose capsule
- Solifenacin
Primary outcomes
- Difference (Pre - Post) in Amplitude (Microvolts) of Urethral Sphincter Activity as Measured by Quantitative Concentric Needle EMG — 2 weeks
Concentric needle EMG was used to measure urethral sphincter activity at 2-3 sites around the urethral meatus before and after 2 weeks of therapy with one of 6 randomly assigned medications. Two methods of quantitative electromyography were performed on all subjects. (1) Multi-Motor Unit Action Potential (MUP) analysis, which has been shown to be the most sensitive technique in distinguishing neuropathic from control muscles; and (2) interference pattern analysis (IPA) which reflects changes in MUP recruitment from weak effort to maximal contraction.
Countries
United States