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The Incidence of Renal Impairment Associated With Polymyxin E Treatment and the Impact of Measuring Colistin Levels
Colistin is a relatively old antibiotic drug which its use has been abandoned through the 1970s because it was considered nephrotoxic. Recently ( the last decade) it has been reappraised because multidrug resistant Gram negative bacteria have emerged causing life threatening infections with no other good enough treatment. Moreover, more controlled studies from the recent years show less toxic effect of the drug. The investigators' study is a prospective study comparing renal function in a group of hospitalized patients with sepsis (infection) receiving intravenous treatment with Colistin (antibiotics) with a control group which its patients receive other non nephrotoxic antibiotics. The investigators' study hypothesis is that patients receiving Colistin would have renal function decline in higher rates than those seen usually in hospitalized patients in the Internal medicine wards with sepsis. Another goal of the study is to find correlation between Colistin levels in the plasma (after Colistin reaches steady state) and nephrotoxicity seen during or after use of this drug.
Details
| Lead sponsor | Shaare Zedek Medical Center |
|---|---|
| Status | COMPLETED |
| Enrolment | 70 |
| Start date | 2009-12 |
| Completion | 2011-01 |
Conditions
- Sepsis
Interventions
- Polymyxin E (Colistin)
- Non-nephrotoxic antibiotics
Primary outcomes
- Serum creatinine changes. — Blood examination every 3 days until discharge
Countries
Israel