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Effects of Atorvastatin on Endothelial Function, Vascular and Myocardial Redox State in High Cardiovascular Risk Patients
The present study constitutes a study examining the effect of atorvastatin on vascular function in high cardiovascular risk patients. For this purpose the investigators will record atorvastatin effects on statin-naïve patients (patients that start statins treatment for first time). More specifically the investigators will study atorvastatin effects on: 1. Endothelial function 2. Arterial elastic properties 3. Systemic Inflammatory/thrombotic mechanisms 4. Vascular and myocardial redox state
Details
| Lead sponsor | Hippocration General Hospital |
|---|---|
| Phase | Phase 4 |
| Status | COMPLETED |
| Enrolment | 72 |
| Start date | 2007-10 |
| Completion | 2012-02 |
Conditions
- Coronary Artery Disease
- HMG-CoA Reductase Inhibitor Toxicity
- Atherosclerosis
- Oxidative Stress
- Endothelial Dysfunction
Interventions
- Atorvastatin, high vs low dose
- Atorvastatin vs Placebo
Primary outcomes
- Vascular Nitric oxide bioavailability (Arm A + B) — At the start and at the end of 2-week treatment period (arm A) and at the start and at the end of 3-day treatment period (arm B)
Countries
Greece